Let’s not drink to that.

“Cheers” star Rhea Perlman and “Taxi” actor Danny DeVito have announced their separation, following a relationship of four decades. The split marks the end of one of Hollywood’s longest, seemingly most stable relationships — made all the more endearing because of the spouses’ miniature stature.

The pair met in the early ’70s, before either was famous, and dated for more than a decade before marrying in 1982. That same year, the Brooklyn-born Perlman would embark on her career-making role, as surly bar waitress Carla Tortelli on “Cheers.” DeVito had achieved TV stardom the previous decade on “Taxi,” and would go on to earn an Oscar nomination as a producer of the 2000 Julia Roberts drama “Erin Brockovich.”

While promoting the 1996 children’s film “Matilda” — which DeVito directed and both starred in — the duo cheerfully talked about their humble early days, when DeVito wooed Perlman with a short film he made about a cockroach in his New York City apartment.

The couple share three kids.

Though only Perlman, 64, is of Jewish background, both are listed as honorary advisers to One Voice, an organization that advocates a two-state solution to the Israeli-Palestinian conflict. Perlman’s next movie role is listed as “Mikvah Lady” in “The Sessions,” a drama with Helen Hunt that claimed two prizes at the Sundance Film Festival.

DeVito, 67, who’s enjoying a career renaissance thanks to popular roles on TV and the London stage, recently tweeted “L’Shanah Tovah” to fans.[blackbirdpie url="https://twitter.com/DannyDeVito/status/247533293564735489"]