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AstraZeneca vaccine cuts virus transmission by two-thirds after one dose – study

Non-peer-reviewed research by vaccine creator Oxford University is hailed by UK politicians as confirming strategy of waiting 12 weeks between doses

This photo issued by the University of Oxford shows of vial of coronavirus vaccine developed by AstraZeneca and Oxford University, in Oxford, England. (John Cairns/University of Oxford via AP)
This photo issued by the University of Oxford shows of vial of coronavirus vaccine developed by AstraZeneca and Oxford University, in Oxford, England. (John Cairns/University of Oxford via AP)

LONDON, United Kingdom — The Oxford-AstraZeneca vaccine significantly reduces virus transmission and is highly protective after a single dose, according to an Oxford University study, which the British government said Wednesday vindicated its inoculation strategy.

“It does show the world that the Oxford jab works, it works well,” Health Secretary Matt Hancock told BBC radio, hailing the study’s findings as “good news.”

“It slows transmission by around two-thirds, so it categorically supports the strategy that we’re undertaking,” Hancock said.

The study’s findings came amid much debate over the effectiveness of the AstraZeneca shot among the elderly.

Britain’s Health Secretary Matt Hancock attends a remote press conference to update the nation on the status of the COVID-19 pandemic, at 10 Downing Street in London, on December 23, 2020. (Kirsty Wigglesworth/Pool/AFP)

Although the European Medicines Agency recommended it for adults of all ages last week, several countries have advised against administering the AstraZeneca vaccine to older people.

Germany has already said it will not advise over 65s to get it, Italy’s medicines agency on Saturday approved the vaccine for all adults but recommended alternatives for people aged over 55, and French President Emmanuel Macron last week said the Oxford-AstraZeneca vaccine was “quasi-ineffective” for those over 65.

The UK has been under lockdown since December with schools closed and no definite end-date, although a review of the situation is expected in mid-February.

The country has had 3.8 million cases and 108,013 deaths.

Dosing schedule

The Oxford study, which is awaiting peer review, found that those who had been vaccinated with a single dose of the vaccine were 67 percent less likely to test positive with a PCR test, “suggesting the potential for a substantial reduction in transmission.”

It also provided backing for the UK’s strategy of administering as many first doses of vaccine to high-risk groups as possible and allowing a 12-week interval before the second dose, which has been criticized by some experts.

The other vaccine already being rolled out in the UK, by Pfizer-BioNTech, was designed to be administered with a shorter interval.

“We are confident that the 12-week dosing schedule is the right one for both of the vaccines that we’re using in the UK,” Hancock said Wednesday.

A health worker prepares doses of the AstraZeneca-Oxford COVID-19 vaccine on the first day of vaccination campaign, in Rabat, Morocco, Jan. 29, 2021 (AP Photo/Mosa’ab Elshamy)

Researchers found that a single dose was 76% effective in preventing virus symptoms after 22 days and for up to 90 days, while it did not prevent asymptomatic illness.

It was more effective to wait 90 days than to administer the second dose, researchers found, “providing further support for current policy.”

The survey had 17,177 participants in Britain, Brazil and South Africa. The data covers the period up to December 7, 2020. None of those studied were hospitalized.

The vaccine invented by scientists at the University of Oxford is being developed and manufactured by AstraZeneca.

The vaccine is cheap to produce and is being sold at cost price. It can also be stored at fridge temperature, while the Pfizer vaccine requires extremely cold storage.

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