Sharpless wins 2nd Nobel -- only fifth person ever to do so

Nobel chemistry prize goes to two Americans and a Dane who make molecules ‘click’

Their work is seen enabling more precise targeting of cancer and other diseases; Bertzozzi is only 8th woman of 189 chemistry laureates; she and Sharpless also Wolf Prize winners

(From left) Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharplesshe, winners of the 2022 Nobel Prize in Chemistry 'for the development of click chemistry and bioorthogonal chemistry.' (Royal Swedish Academy of Sciences)
(From left) Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharplesshe, winners of the 2022 Nobel Prize in Chemistry 'for the development of click chemistry and bioorthogonal chemistry.' (Royal Swedish Academy of Sciences)

STOCKHOLM (AP) — Three scientists were jointly awarded this year’s Nobel Prize in chemistry on Wednesday for developing a way of “snapping molecules together” that can be used to design better medicines, including ones that target diseases such as cancer more precisely.

Americans Carolyn R. Bertozzi and K. Barry Sharpless, and Danish scientist Morten Meldal were cited for their work on click chemistry and bioorthogonal reactions, which are used to make cancer drugs, map DNA and create materials that are tailored to a specific purpose.

“It’s all about snapping molecules together,” said Johan Aqvist, a member of the Royal Swedish Academy of Sciences that announced the winners at the Karolinska Institute in Stockholm.

Sharpless, 81, who previously won a Nobel Prize in 2001 and is now the fifth person to receive the award twice, first proposed the idea of connecting molecules using chemical “buckles” around the turn of the millennium, Aqvist said.

“The problem was to find good chemical buckles,” he said. “They have to react with each other easily and specifically.”

Meldal, 68, based at the University of Copenhagen and Sharpless, who is affiliated with Scripps Research in California, independently found the first such candidates that would easily snap together with each other but not with other molecules, leading to applications in the manufacture of medicines and polymers.

2022 Nobel chemistry prize winner Carolyn R. Bertozzi. (Stanford Media Relations via AP)

Bertozzi, 55, who is based at Stanford University, “took click chemistry to a new level,” the Nobel panel said.

She found a way to make the process work inside living organisms without disrupting them, establishing a new method known as bioorthogonal reactions. Such reactions are now used to explore cells, track biological processes and design drugs that can target diseases such as cancer more precisely.

“Doing chemistry inside human patients to make sure that drugs go to the right place and stay away from the wrong place,” Bertozzi explained.

Berzotti won Israel’s Wolf Prize for chemistry this year, and Sharpless won it in 2001.

Bertozzi is the only woman among the seven Nobel laureates honored so far this year, with women vastly under-represented in the history of the prizes, especially in the science disciplines.

The chemist — who as an undergraduate at Harvard played keyboards in a band called Bored of Education with future Rage Against the Machine guitarist Tom Morello — is only the eighth woman to win a Nobel Chemistry Prize, out of 189 recipients.

Speaking by phone at a news conference following the announcement, Bertozzi said she was “absolutely stunned” to receive the prize.

“I’m still not entirely positive that it’s real, but it’s getting realer by the minute,” she said.

Speaking to The Associated Press by Zoom, Bertozzi said one of the first people she called after being wakened by the call around 2 a.m. was her father, William Bertozzi, a retired physicist and night owl, who was still awake watching TV.

“Dad, turn down the TV, I have something to tell you,” she said she told him. After assuring him nothing was wrong he guessed the news. “You won it, didn’t you?”

One of three daughters, Bertozzi said she was “fortunate because I grew up with parents that were very supportive, evangelical almost, about having their girls participate in the sciences.”

Bertozzi — whose research is supported by the Howard Hughes Medical Institute, which also supports The Associated Press’ Health and Science Department — said she was grateful for the energy and enthusiasm that a Nobel Prize win will inject into the field.

2022 Nobel Prize in Chemistry co-winner Professor Morten Meldal meets the press at the University of Copenhagen, on October 5, 2022. (Philip Davali/Ritzau Scanpix/AFP)

Meldal said he received the call from the Nobel panel about half an hour before the public announcement. “They … told me not to tell anyone,” he told the AP, adding that he just sat in his office, shaking a bit. “This is a huge honor.”

Meldal started out as an engineer, “but I wanted to understand the world so I thought chemistry would give me the solutions.”

Jon Lorsch, director of the U.S. National Institute of General Medical Sciences, which supports the work of Bertozzi and Sharpless, described click chemistry and bioorthogonal chemistry as “sort of like molecular Lego — you have a group on one molecule that specifically attaches to a group on another molecule,” like Lego clicking together.

“That makes it possible to attach molecules in very specific pre-defined ways,” he said, and gives scientists a very precise tool to build complex new molecules that can be used for drugs, synthetic materials and other uses.

However, the first iteration of click chemistry could not initially be used to work on living cells. “The original click chemistry used copper as a catalyst to join molecules,” Lorsch said. “But the trouble is that copper is toxic to most living systems at higher concentrations.”

Bertozzi then devised a way to jumpstart the reactions without copper or other toxic solvents — broadening the applications of the molecular Lego to human and animal tissues.

“Being able to work without dangerous solvents, opened many new doors — it enabled scientists to work on new types of reactions that actually take place within the human body,” said Angela Wilson, president of the American Chemical Society.

For example, that has allowed scientists to attach dyes to cancer cells to track their movements and analyze how they differ from healthy tissue.

Wilson believes that the advances of this year’s Nobel laureates “will allow more individualized medicine in the future because we can really track things much better within the human body.”

Last year, the prize was awarded to scientists Benjamin List and David W.C. MacMillan for finding an ingenious and environmentally cleaner way to build molecules that the Nobel panel said is “already benefiting humankind greatly.”

In this 2001 file photo, 2022 Nobel Laureate K. Barry Sharpless speaks to a room full of reporters and colleagues at Scripps Research Institute in La Jolla, Ca., after winning the 101st Nobel Prize in Chemistry, October 10, 2001. (Andrew SIlk/AFP)

Only four individuals before Sharpless have achieved the feat of winning two Nobel Prizes, including Polish-born Frenchwoman Marie Curie, who won the chemistry prize in 1911 after first winning the physics prize in 1903.

She was followed by American Linus Pauling who won for chemistry in 1954 and peace in 1962. American John Bardeen won the physics prize in 1956 and 1972, and Britain’s Frederick Sanger won the chemistry prize in 1958 and 1980.

A week of Nobel Prize announcements kicked off Monday with Swedish scientist Svante Paabo receiving the award in medicine for unlocking secrets of Neanderthal DNA that provided key insights into our immune system.

Three scientists won the prize in physics Tuesday. Frenchman Alain Aspect, American John F. Clauser and Austrian Anton Zeilinger had shown that tiny particles can retain a connection with each other even when separated, a phenomenon known as quantum entanglement, that can be used for specialized computing and to encrypt information.

The awards continue with literature on Thursday. The 2022 Nobel Peace Prize will be announced Friday and the economics award on Monday.

The prizes carry a cash award of 10 million Swedish kronor (nearly $900,000) and will be handed out on December 10. The money comes from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel, in 1895.

AFP and Times of Israel staff contributed to this article.

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