Immune system ‘remembers’ to fight off coronavirus for at least 6 months: study

Research by UN and Switzerland shows that even though the level of antibodies fade, body maintains sufficient memory B cells, and they manage to stave off reinfection

Illustrative: Red blood cells alongside antibodies in an artery. (urfinguss; iStock by Getty Images)
Illustrative: Red blood cells alongside antibodies in an artery. (urfinguss; iStock by Getty Images)

PARIS, France (AFP) — People may be able to fight off reinfection for at least six months after they recover from COVID-19, thanks to cells that can “remember” the virus, according to research published Monday.

Researchers in the United States and Switzerland studied dozens of people who had recovered from COVID-19 and found that, while their antibodies may fade over time, they maintained levels of specific memory B cells.

These cells can remember the pathogen and can, if faced with reinfection, prompt the immune system to reinitiate the production of virus-fighting antibodies.

“Memory responses are responsible for protection from reinfection and are essential for effective vaccination,” concluded the study published in the journal Nature. “The observation that memory B cell responses do not decay after 6.2 months, but instead continue to evolve, is strongly suggestive that individuals who are infected with SARS-CoV-2 could mount a rapid and effective response to the virus upon re-exposure.”

The authors assessed 87 people with a confirmed COVID-19 diagnosis at a little over one month and six months after infection.

While they found that virus-neutralizing antibody activity decreased with time, the number of memory B cells remained unchanged.

Researchers said their study indicated that the memory B cell response against the coronavirus evolves during the six months after infection, in the presence of viral remnant proteins in the body — enabling the cells to produce more potent antibodies.

How long people can fight off reinfection to the new coronavirus and what immune process is involved are key to predicting the dynamics of the pandemic.

Previous research had caused concern by showing that neutralizing antibodies can decline quickly after infection with the SARS-CoV-2 virus. But more recent studies have highlighted the role of other parts of the immune system in longer-term immunity.

One paper published in the journal Science this month suggested that nearly all major parts of the immune system that can learn to recognize and repel a new pathogen could continue to respond to the virus for at least eight months.

This included protein spike specific memory B cells, which the researchers found actually increased in the blood six months after infection.

The paper was based on analyses of blood samples from 188 COVID-19 patients.

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