Police say that the attack on the West Bank checkpoint south of Jerusalem was carried out by a cell of three gunmen who arrived by car and opened fire.
Police say all three were killed by Israeli forces at the scene.
A large force of police, Border Police and IDF troops are carrying out searches in the area, police say, adding that sappers are also operating at the scene.
The road that links Jerusalem with settlements in the southern West Bank is closed.
Magen David Adom reports that four wounded people at the scene are being taken to hospital.
This includes a man in his 20s in critical condition, two people — a young woman in her early 20s and a man aged 32 — in moderate condition, and a young man who was lightly wounded.
All four suffered gunshot wounds.
In addition, three people at the scene were treated for symptoms of traumatic stress, MDA says.
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