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‘Breakthrough’ treatment slashes virus death risk, preliminary UK study finds

Small-scale and non-peer-reviewed research shows inhaling the protein interferon beta reduces likelihood of developing severe disease by 79%

COVID-19 patients receive treatment at the Salgado Filho Municipal Hospital in Rio de Janeiro, Brazil, May 24, 2020. (AP/Leo Correa)
COVID-19 patients receive treatment at the Salgado Filho Municipal Hospital in Rio de Janeiro, Brazil, May 24, 2020. (AP/Leo Correa)

An aerosol-based drug treatment could drastically reduce the number of new coronavirus patients dying from the disease or requiring intensive care, according to preliminary results released Monday by a British biotech firm.

In a randomized trial of 100 patients admitted to hospital with COVID-19, those who received an inhaled formula of the protein interferon beta had a 79 percent lower risk of developing severe disease, as compared to those who received a placebo.

They were also more than twice as likely to make a full recovery compared with the control group.

The firm behind the treatment, which is known as SNG001, said the preliminary results suggested “a major breakthrough” in the pandemic.

“We are all delighted with the trial results announced today, which showed that SNG001 greatly reduced the number of hospitalized COVID-19 patients who progressed from requiring oxygen to requiring ventilation,” said Richard Marsden, CEO of Synairgen.

The results published Monday have not yet been peer-reviewed and the sample size is relatively small.

But if confirmed the treatment could revolutionize the way COVID-19 is dealt with in hospitals.

Interferon beta is a naturally occurring protein, commonly used to treat multiple sclerosis.

It forms part of the body’s natural fight against infection, and the novel coronavirus suppresses its production in an attempt to evade an immune response.

Delivering the protein directly into the lungs of patients is designed to trigger a robust immune response to the virus, even in patients whose immune system is already weakened by infection.

“The results confirm our belief that interferon beta… has huge potential as an inhaled drug to be able to restore the lung’s immune response,” said Tom Wilkinson, professor or respiratory medicine at the University of Southampton.

He said the trial showed SNG001 was effective in “enhancing protection, accelerating recover, and countering the impact of SARS-CoV-2 virus.”

There are currently a number of treatments available for patients hospitalized with COVID-19.

Last month, a Britain-based team of researchers lead by the University of Oxford announced that they had successfully reduced the risk of death among seriously ill patients by administering the commonly available steroid dexamethasone.

Hebrew University Prof. Yaakov Nahmias has said that, based on research he has conducted on infected human tissue, a widely-used anti cholesterol drug called fenofibrate can “downgrade” the danger-level of the coronavirus to that of a common cold.

Several countries have also issued the emergency authorization for treatment with anti-viral remdesivir.

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