A Palestinian opened fire on the Gilboa crossing between Israel and the northern West Bank Friday afternoon.
No Israelis were hurt in the attack.
According to a Defense Ministry statement, the Palestinian attacker opened fire from several dozen yards away. A guard identified the assailant and returned fire, apparently wounding him.
A Palestinian commercial vehicle then sped up to the shooter, who got in and escaped.
Security forces launched a manhunt for the attacker, who was believed to have come from around the nearby Palestinian city of Jenin.
According to Channel 10, Palestinian Authority police may have arrested the shooter while he fled the scene.
Times of Israel staff contributed to this report.