Prime Minister Benjamin Netanyahu on Wednesday excoriated world powers over their dogged pursuit of a nuclear deal with Iran, pointing to recent statements by officials in Tehran — notably their calls to eliminate Israel — as evidence of the Islamic Republic’s unwillingness to compromise on its nuclear ambitions and campaign of “terror, subjugation and conquest.”

In tones of moral outrage, he issued a brief, infuriated statement to camera, protesting that the talks were continuing in Lausanne even as Iran reiterated its insistent goal of destroying the Jewish state.

“Yesterday an Iranian general brazenly declared, and I quote, ‘Israel’s destruction is nonnegotiable,'” Netanyahu began, referring to a statement by Mohammad Reza Naqd, the commander of the Basij militia of Iran’s Revolutionary Guards.

“But evidently, giving Iran’s murderous regime a clear path to the bomb is negotiable,” he said. “This is unconscionable.”

Netanyahu’s comments came as diplomats from Iran and a group of six world powers, led by the United States, resumed negotiations over the terms of a nuclear deal, hours after a deadline for such a deal elapsed.

He charged that Iran’s actions and ongoing “aggression” across the Middle East proved it did not intend to give up its nuclear and regional ambitions.

“I agree with those who have said that Iran’s claim that its nuclear program is only for peaceful purposes doesn’t square with Iran’s insistence on keeping underground nuclear facilities, advanced centrifuges, and a heavy water reactor,” he said. “Nor does it square with Iran’s insistence on developing ICBMs [Intercontinental Ballistic Missiles], and its refusal to come clean with the International Atomic Energy Agency on its past weaponization efforts.

“At the same time, Iran is accelerating its campaign of terror, subjugation and conquest throughout the region, most recently in Yemen,” he continued.

Netanyahu’s reference to “those who have said” Iran does not require such capabilities marked the second time in two days that he has obliquely referred to comments made by President Barack Obama at the Saban Conference in December 2013, without citing Obama by name. The two leaders are bitterly at odds over strategies for thwarting Iran.

The prime minister claimed that “the concessions offered to Iran in Lausanne would ensure a bad deal that would endanger Israel, the Middle East and the peace of the world,” and called on the international community “to insist on a better deal… which would significantly roll back Iran’s nuclear infrastructure” and “link the eventual lifting of the restrictions on Iran’s nuclear program to a change in Iran’s behavior.”

He called on world powers to ensure that Iran “stop its aggression in the region, stop its terrorism throughout the world, and stop its threats to annihilate Israel.”

That should be nonnegotiable. And that’s the deal that the world powers must insist upon,” he concluded.

The negotiators resumed talks in the Swiss resort town of Lausanne Wednesday, just hours after abandoning a March 31 deadline to reach the outline of a deal and agreeing to press on. However, as the discussions dragged on, three of the six foreign ministers involved left the talks, and prospects for agreement remained uncertain.

US Secretary of State John Kerry (L) gestures waiting for the opening of a plenary session with P5+1 ministers, European Union and Iranian minister on Iran nuclear talks at the Beau Rivage Palace Hotel in Lausanne, Switzerland, on March 31, 2015. (photo credit: AFP/FABRICE COFFRINI)

US Secretary of State John Kerry (L) gestures waiting for the opening of a plenary session with P5+1 ministers, European Union and Iranian minister on Iran nuclear talks at the Beau Rivage Palace Hotel in Lausanne, Switzerland, on March 31, 2015. (photo credit: AFP/FABRICE COFFRINI)

Claiming enough progress had been made to warrant an extension after six days of intense bartering, and eager to avoid a collapse in the discussions, US Secretary of State John Kerry and his British and German counterparts huddled in Lausanne to continue a marathon effort to bridge still significant gaps and hammer out details of a framework accord.

The foreign ministers of China, France and Russia all departed Lausanne overnight, although the significance of their absence, particularly when the broader group meets with Iranian Foreign Minister Mohammed Javad Zarif, was not clear.

If they succeed, those understandings would form the basis for a comprehensive detailed agreement to be reached by the end of June.

After the talks last broke in the early hours of Wednesday, Zarif said solutions to many of the problems had been found and that documents attesting to that would soon be drafted. Other officials were more skeptical.

Asked how high the chances of success were, German Foreign Minister Frank-Walter Steinmeier said: “I cannot say.” And British Foreign Secretary Philip Hammond said Iran might still not be ready to accept what is on the table.

“I’m optimistic that we will make further progress this morning but it does mean the Iranians being willing to meet us where there are still issues to deal with,” Hammond told British reporters. “Fingers crossed and we’ll hope to get there during the course of the day.”

Although the Chinese, French and Russian ministers left their deputies in charge, Kerry postponed his planned Tuesday departure to stay in Lausanne, and an Iranian negotiator said his team would stay “as long as necessary” to clear the remaining hurdles.

Officials say their intention is to produce a joint statement outlining general political commitments to resolving concerns about Iran’s nuclear program in exchange for sanctions relief, and their intention to begin a new phase of negotiations to get to that point. In addition, they are trying to fashion other documents that would lay out in more detail the steps they must take by June 30 to meet those goals.

The additional documents would allow the sides to make the case that the next round of talks will not simply be a continuation of negotiations that have already been twice extended since an interim agreement between Iran, the United States, Russia, China, Britain, France and Germany was concluded in November 2013. President Barack Obama and other leaders, including Iran’s, have said they are not interested in a third extension.

Russian Foreign Minister Sergey Lavrov (center) and others wait for a P5+1 meeting at the Beau-Rivage Palace Hotel in Lausanne, Switzerland, on March 28, 2015. (photo credit: AFP/Brendan Smialowski, Pool)

Russian Foreign Minister Sergey Lavrov (center) and others wait for a P5+1 meeting at the Beau-Rivage Palace Hotel in Lausanne, Switzerland, on March 28, 2015. (photo credit: AFP/Brendan Smialowski, Pool)

But if the parties agree only to a broad framework that leaves key details unresolved, Obama can expect stiff opposition at home from members of Congress who want to move forward with new, stiffer Iran sanctions. Lawmakers had agreed to hold off on such a measure through March while the parties negotiated. The White House says new sanctions would scuttle further diplomatic efforts to contain Iran’s nuclear work and possibly lead Israel to act on threats to use military force to accomplish that goal.

And despite the progress that diplomats said merited the extension of talks into Wednesday, officials said the differences notably included issues over uranium enrichment, the status of Iran’s enriched uranium stockpiles, limits on Iran’s nuclear research and development, and the timing and scope of sanctions relief.

The US and its negotiating partners are demanding curbs on Iranian nuclear activities that could be used to make weapons, and they say any agreement must extend the time Tehran would need to produce a weapon from the present several months to at least a year. The Iranians deny such military intentions, but they are negotiating with the aim that a deal will end sanctions on their economy.