Israeli security guards shot a Palestinian man who ran at a checkpoint near the Palestinian city of Tulkarem in the northern West Bank on Monday, the Defense Ministry said.
Guards at the Te’enim checkpoint called on the man to stop, and shot him in the lower body when he did not respond, the ministry said in a statement.
He was seriously injured, and medical personnel evacuated him to a hospital.
The Defense Ministry did not say the man was armed.
The incident came with tensions running high after some 30,000 Palestinians took part in demonstrations along the Gaza border on Friday.
There were discrepancies in Palestinian reports on the death toll from the clashes. While Hamas claimed Monday that 18 had died, the official news agency of the Palestinian Authority had the number at 16. Israel has no official death toll figures.
The Israel Defense Forces said Saturday that at least 10 of those killed were members of Palestinian terror groups, including Hamas, and gave details of their roles.
There were no casualties among Israelis.
Smaller protests also broke out in the West Bank, where dozens were reported injured in a series of clashes with troops in Nablus and elsewhere.