Israeli forces shelled the Syrian city of Quneitra, Syrian state media reported Monday night.
According to the state-run SANA news agency, Israeli tank shells targeted a hospital in Quneitra and a nearby observation post.
Quneitra lies just across the border on the Golan Heights, in the demilitarized zone between the countries.
The Israeli military did not immediately respond to the report.
According to SANA, the shelling caused material damage but no casualties.
Israel has carried out hundreds of airstrikes in Syria to thwart attempts to smuggle weapons to the Hezbollah terror group and keep Iranian-backed forces from entrenching themselves near the border.
A report last week indicated that advanced Russian S-300 air defense batteries had been set up in Syria to stop Israeli attacks.
On Monday, Russian Deputy Foreign Minister Sergei Ryabkov that Israeli airstrikes on Syria are unlawful and cannot be justified.