The Temple Mount in Jerusalem was closed to visitors on Wednesday after Arab youths shot fireworks at policemen out of the al-Aqsa Mosque.
The youths were said to have attacked the policemen from within the mosque.
Following the incident, security forces arrived at the scene and closed the religious site to visitors.
On Sunday, the Temple Mount was closed to Jews after a fight between Jews and Muslim worshippers broke out on the plaza.
According to police, the scuffle began after Muslims took exception to a group of Jews at the site singing Hanukkah songs, Israel Radio reported.
Two Jews and two Muslims were arrested.
The sensitive Temple Mount area, holy to both Muslims and Jews, is controlled by the Muslim Waqf, but security is overseen by Israel. Non-Muslims are allowed to visit, but all non-Muslim religious ritual is banned.
Israeli police and Waqf guards keep close tabs on visitors identifiable as religious Jews. If any are seen moving their lips in prayer, or prostrating themselves on the smooth stones of the shrine, they are expelled and sometimes detained.
The site, home to the al-Aqsa Mosque and the Dome of the Rock shrine, is revered as the location of both ancient Jewish temples.
In September, there were several clashes between police and Palestinian youths on the mount and security forces used tear gas and stun grenades to disperse the crowds.
Tensions were raised by an influx of Jewish visitors to the site during the Sukkot holiday. As a result, at the end of September, Jerusalem police closed the Temple Mount to non-Muslim visitors, citing security concerns — a surprise announcement that caused many holiday pilgrims and tourists to be turned away at the site.
Lazar Berman and Stuart Winer contributed to this report.