Three people were killed after their cars collided along Route 6 near the southern city of Kiryat Gat on Thursday evening.
The Magen David Adom ambulance service said in a statement that a man and a woman in their 40s and another man in his 30s were pronounced dead at the scene following the accident at the Kiryat Gat interchange.
Paramedics said they found the cars “crushed” at the scene, along with the three passengers, who were all unconscious and not breathing.
Police discovered during a preliminary investigation that one of the drivers lost control of his vehicle and crossed into the opposite lane, crashing into the oncoming car.
The accident came hours after two Israelis were killed and five injured in a collision in Egypt’s Sinai desert.
In a separate tragedy on Wednesday, a 6-year-old Israeli boy was killed and six were wounded in a crash along Route 60 near the West Bank city of Ariel.
According to the latest data from the Central Bureau of Statistics, 183 people were killed on Israeli roads between January and June.
Last year, 361 people died on Israel’s roads, according to the National Road Safety Authority.