A team of Israeli researchers at the Technion has discovered two proteins that can suppress cancer and control the cells’ growth and development.
The study was conducted in the laboratory of Prof. Aaron Ciechanover, an Israeli Nobel-prize winner in chemistry, and led by Dr. Yelena Kravtsova-Ivantsiv. The team included research students and physicians from the Rambam, Carmel and Hadassah Medical Centers.
In a paper published in the journal Cell last week, the researchers showed how the proteins could repress cancerous tissues and detailed how a high concentration of a protein called KPC1 and another called p50 in the tissue can protect it from cancerous tumors.
The research also detailed how the ubiquitin process — a cell system responsible for breaking down damaged proteins that can harm cells and tissues and co-discovered by Ciechanover, for which he won the Nobel — has a role in the mechanism.
The study was done on human tumors grown in mice, and samples of human tumors.
Ciechanover told PR Newswire that many more years of research are needed “to establish the research and gain a solid understanding of the mechanisms behind the suppression of the tumors. The development of a drug based on this discovery is a possibility, although not a certainty, and the road to such a drug is long and far from simple.”